Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?

Central nervous system injury, specifically traumatic brain and spinal cord can have significant long lasting effects. There are no comprehensive treatments to combat the injury sequalae of events that occurring following a central trauma. Herein we discuss potential for epothilone family microtubule stabilizing agents improve outcomes experimentally induced These drugs, which able cross blood-brain barrier, may hold great promise treatment trauma current literature presents extensive range beneficial effects these drugs in animal models. Importantly, effect epothilones vary our most recent contributions this field indicate efficacy is dependent upon age animals. Therefore, present case greater emphasis be placed when using an intervention aimed at neural regeneration highlight importance tailoring therapeutic regime clinic patient promote improved outcomes.